You can decrease your likelihood of developing stomach issues by taking NSAIDs with food, milk, or an antacid. The risk of developing stomach issues is higher for people who: If you experience any of the following symptoms, stop using the NSAID immediately and call your healthcare provider: Some ulcers can even lead to internal bleeding. In more serious cases, taking NSAIDs can irritate your stomach lining enough to cause an ulcer. As a result, taking NSAIDs can contribute to minor gastrointestinal problems, including: NSAIDs block COX-1, which helps protect your stomach lining. Celecoxib (Celebrex) is currently the only selective COX-2 inhibitor available by prescription in the United States. Selective COX-2 inhibitors are NSAIDs that block more COX-2 than COX-1. Nonspecific NSAIDs that are available with a prescription in the United States include: Low-dose aspirin isn’t typically categorized as an NSAID. Nonspecific NSAIDs that are available over the counter in the United States include: Most NSAIDs are nonspecific, which means that they block both COX-1 and COX-2. Your body produces two types of COX: COX-1 and COX-2.ĬOX-1 protects your stomach lining, while COX-2 causes inflammation. NSAIDs block the enzyme cyclooxygenase (COX) from creating prostaglandins. This is because it’s easier on your stomach than other NSAIDs. The prescription drug celecoxib (Celebrex) is often prescribed for long-term management of arthritis symptoms. NSAIDs tend to be inexpensive and easily accessible, so they’re often the first medications prescribed to people with arthritis. NSAIDs are especially important for managing the symptoms of arthritis, such as joint pain, inflammation, and stiffness. inflammation and stiffness caused by arthritis and other inflammatory conditions. In fact, NSAIDs can be useful in reducing many types of discomfort, including: Prostaglandins also play a role in controlling your body temperature.īy inhibiting the effects of prostaglandins, NSAIDs help relieve your pain and bring down your fever. NSAIDs work by blocking prostaglandins, which are substances that sensitize your nerve endings and enhance pain during inflammation.
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